Welcome!

The Lutsenko Lab at Johns Hopkins University School of Medicine Department of Physiology is focused on the molecular mechanisms of copper homeostasis in normal and diseased cells.

Copper is a fascinating biological metal that is indispensable for such fundamental processes such as respiration, myelination of neurons, biosynthesis of neurotransmitters, energy metabolism, pigmentation, iron transport, immune response, and many others. The role of copper as a cofactor of key metabolic enzymes has been well established. Recent studies uncovered additional roles for copper in cell differentiation, signaling, coordination of functions of intracellular compartments, and cell-to-cell communications.

Our laboratory investigates the new regulatory functions of copper. We use a broad spectrum of approaches, which include biochemical studies of molecules involved in copper transport and homeostasis, investigation of cellular processes regulated by copper using cell and tissue imaging, and the development and characterization of animal models for disorders or copper misbalance. If you are an independent thinker and like to explore new ideas, concepts, and methodology, we welcome you to the lab!

Recent Publications:

 

Lab News:

Lutsenko lab group picture at the department retreat.

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